Esketamine (Spravato®) for treatment resistant depression.

We know how disheartening it can feel when you’ve tried therapy, medications, or other treatments—and the depression still lingers. If you’ve been showing up and doing the work but continue to feel stuck, adding esketamine (Spravato®) to your treatment plan might be a next step worth exploring.

Esketamine is an FDA-approved nasal spray that’s used alongside an oral antidepressant to treat treatment-resistant depression. It works differently than traditional medications, targeting the brain’s glutamate system—which may help “reboot” mood pathways that have become rigid or unresponsive over time.

At Redbud, esketamine is administered in a calm, supportive environment. You’ll come into our office for each session, where you’ll self-administer the nasal spray under the guidance of our trained staff. Then, you’ll stay with us for about two hours while we monitor you in a quiet, comfortable space. Because of the way esketamine affects thinking and coordination, you’ll need someone to drive you home afterward.

Esketamine is typically given twice a week at first, with sessions gradually tapering as your symptoms improve. Some people notice changes within a few weeks—others take a little longer. Throughout it all, we’ll be there to check in, track your progress, and make sure you feel supported every step of the way.

This treatment isn’t right for everyone, but for those who haven’t found relief with other options, it can offer new hope. If you’re curious about whether esketamine might be a good fit for you, we’re here to talk through your questions, without pressure—just honest, thoughtful guidance.

You don’t have to keep feeling mired in depression. We’re here, and we’re ready to help.

Change is possible.

Change is possible.

Questions?

FAQs

  • During a session, you’ll self-administer the nasal spray in a quiet, private room with our staff nearby. You’ll then rest and be monitored for about two hours. Some people describe the experience as dreamlike, floaty, or mildly out of body—as if their thoughts are a bit more distant or slowed down, but many people do not and such experiences are not required for treatment effects. Most people feel calm by the end of the session, and the effects usually wear off within a few hours.

    Common side effects can include dizziness, nausea, feeling disconnected or “out of it,” mild sedation, or a temporary increase in blood pressure. These are typically short-lived and resolve during the observation period. We’ll be there to monitor how you’re feeling and make sure you’re comfortable and safe throughout your time with us.

    You’ll need someone to drive you home after the session, and we recommend taking the rest of the day to rest and recharge.

  • During a session, you’ll self-administer the nasal spray in a quiet, private room with our staff nearby. You’ll then rest and be monitored for about two hours.

    Most people feel calm by the end of the session, and the effects usually wear off within a few hours.

    You’ll need someone to drive you home after the session, and we recommend taking the rest of the day to rest and recharge.

  • Esketamine is usually given twice a week for the first four weeks, followed by a tapering schedule based on how you’re responding. Over time, treatments typically become less frequent. We’ll work with you to create a plan that fits your needs and check in regularly to make sure you’re getting the support you need.

  • Many insurance plans do cover esketamine for treatment-resistant depression, especially when other medications have not been effective. Coverage can vary, so our team will work with you to check your benefits and walk you through what to expect—no surprises, just clear information and support.